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NQO1, human recombinant protein
NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreducta
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P15559 |
|---|---|
| Calculated MW | ~30.0 kDa. Human NQO1 (aa 1-274) is fused at the C-terminus to a His-tag. |
| Gene ID | 1728 |
|---|---|
| Gene Symbol | NQO1 |
| Other Names | NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Target/Specificity | NQO1 |
| Format | Liquid |
| Storage | -20°C; 0.2 µm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT. |
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Provided below are standard protocols that you may find useful for product applications.
Background
NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxifying enzyme and is involved in the body’s protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimer’s disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.
References
Jaiswal A.K.,et al.J. Biol. Chem. 263:13572-13578(1988).
Jaiswal A.K.,et al.Biochemistry 30:10647-10653(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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