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NQO1, human recombinant protein

NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreducta

Product info
Primary Accession P15559
Calculated MW ~30.0 kDa. Human NQO1 (aa 1-274) is fused at the C-terminus to a His-tag.
Additional Info
Gene ID 1728
Gene Symbol NQO1
Other Names NAD(P)H Dehydrogenase (Quinine) 1 (NQO1); Quinone Reductase 1 (QR1); DT-Diaphorase (DTD); Azoreductase; Phylloquinone Reductase; Menadione Reductase; Dioxin-inducible 1; Disphorase-4 (DIA4); NAD(P)H Quinone Oxireductase; Quinone Oxidoreductase 1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity NQO1
Format Liquid
Storage -20°C; 0.2 µm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.
Citations (0)

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NQO1 is a cytosolic antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites and their derivatives by using NAD (P)H as an electron donor. Thus NQO1 acts as a detoxifying enzyme and is involved in the body’s protection against oxidative stress. NQO1 acts as a protein chaperone, one of its targets being p53. In humans NQO1 is expressed at high levels in adipocytes and its expression levels are positively correlated with adiposity, glucose tolerance, and makers of liver dysfunction. Altered expression of NQO1 is associated with Alzheimer’s disease. NQO1 is abnormally elevated in many types of solid tumors and may represent a useful biomarker of pancreatic cancer.


Jaiswal A.K.,et al.J. Biol. Chem. 263:13572-13578(1988).
Jaiswal A.K.,et al.Biochemistry 30:10647-10653(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 225.00
$ 735.00
Cat# PBV11180r
(40 western blots)
Availability: 5-7days
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