FNDC5, human/mouse recombinant protein
Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2
|Calculated MW||~16.0 kDa. (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.|
|Other Names||Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2|
|Application Notes||Reconstitute with 100 µl sterile distilled water.|
|Storage||-20°C; Lyophilized in PBS.|
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Provided below are standard protocols that you may find useful for product applications.
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bostrom P.,et al.Nature 481:463-468(2012).
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