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Human CellExp Netrin-1, human recombinant protein
NTN1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95631 |
|---|---|
| Calculated MW | ~80.0 kDa. Human netrin-1 (aa 25-604) is fused at the C-terminus to a FLAG®-tag. |
| Gene ID | 9423 |
|---|---|
| Gene Symbol | NTN1 |
| Other Names | NTN1 |
| Gene Source | Human |
| Source | HEK293 cells |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | Induces axon outgrowth. |
| Target/Specificity | Netrin-1 |
| Application Notes | Reconstitute with 100 µl sterile distilled water. |
| Format | Lyophilized |
| Storage | -20°C; Lyophilized in PBS with trehalose and Brij 35. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.
References
Meyerhardt J.A.,et al.Cell Growth Differ. 10:35-42(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L.,et al.Nature 431:80-84(2004).
Liu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
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