|Calculated MW||~80.0 kDa. Human netrin-1 (aa 25-604) is fused at the C-terminus to a FLAG®-tag.|
|Results||Induces axon outgrowth.|
|Application Notes||Reconstitute with 100 µl sterile distilled water.|
|Storage||-20°C; Lyophilized in PBS with trehalose and Brij 35.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.
Meyerhardt J.A.,et al.Cell Growth Differ. 10:35-42(1999).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Li J.,et al.Mol. Cell. Proteomics 9:2517-2528(2010).
Mazelin L.,et al.Nature 431:80-84(2004).
Liu G.,et al.Proc. Natl. Acad. Sci. U.S.A. 106:2951-2956(2009).
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