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Alkaline Phosphatase, Calf Intestine recombinant protein

ALP-1, ALPPL2, ALPPL, ALPP, ALP, PALP, PLAP, PLAP-1.

     
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Product info
Primary Accession P09487
Calculated MW 57193 Da
Additional Info
Gene ID 280994
Gene Symbol ALPL
Other Names ALP-1, ALPPL2, ALPPL, ALPP, ALP, PALP, PLAP, PLAP-1
Gene Source Calf
Source Calf Intestine
Assay&Purity SDS-PAGE; ≥98%
Assay2&Purity2 N/A;
Results 3,000-6,000 U/mg protein
Target/Specificity Alkaline Phosphatase
Application Notes Reconstitute in distilled water or dilute buffer.
Format Freeze Dried
Storage -20°C; Lyophilized without any additives.
Citations (0)
citation

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Background

Alkaline Phosphatase (ALP) is a hydrolase enzyme responsible for removing phosphate groups in the 5- and 3- positions from many types of molecules, including nucleotides, proteins, and alkaloids. In humans, alkaline phosphatase is present in all tissues throughout the entire body, but is particularly concentrated in liver, bile duct, kidney, bone, and the placenta. The optimal pH for the enzyme activity is pH 10 in standard conditions. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized.

References

Garattini E.,et al.Gene 59:41-46(1987).
Hua J.-C.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2368-2372(1986).

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Discontinued
Cat# PBV11192r-10
Size:

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