|Calculated MW||20.5 kDa|
|Other Names||A18HNRNP, CIRP, CIRBP|
|Application Notes||Detailed reconstitution instructions are sent along with the product|
|Storage||-20°C; Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.
Nishiyama H.,et al.Gene 204:115-120(1997).
Sheikh M.S.,et al.J. Biol. Chem. 272:26720-26726(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Yang C.,et al.J. Biol. Chem. 276:47277-47284(2001).
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