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>   home   >   Products   >   Proteins   >   CIRBP / Cold-inducible RNA-binding protein, human recombinant protein   

CIRBP / Cold-inducible RNA-binding protein, human recombinant protein

A18HNRNP, CIRP, CIRBP

     
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Product info
Primary Accession Q14011
Calculated MW 20.5 kDa
Additional Info
Gene ID 1153
Gene Symbol CIRBP
Other Names A18HNRNP, CIRP, CIRBP
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Target/Specificity CIRBP
Application Notes Detailed reconstitution instructions are sent along with the product
Format Lyophilized
Storage -20°C; Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol.
Citations (0)

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Background

CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.

References

Nishiyama H.,et al.Gene 204:115-120(1997).
Sheikh M.S.,et al.J. Biol. Chem. 272:26720-26726(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Yang C.,et al.J. Biol. Chem. 276:47277-47284(2001).

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Cat# PBV11196r
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