CIRBP / Cold-inducible RNA-binding protein, human recombinant protein
A18HNRNP, CIRP, CIRBP
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q14011 |
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Calculated MW | 20.5 kDa |
Gene ID | 1153 |
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Gene Symbol | CIRBP |
Other Names | A18HNRNP, CIRP, CIRBP |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥90% |
Assay2&Purity2 | N/A; |
Recombinant | Yes |
Target/Specificity | CIRBP |
Application Notes | Detailed reconstitution instructions are sent along with the product |
Format | Lyophilized |
Storage | -20°C; Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3'untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.
References
Nishiyama H.,et al.Gene 204:115-120(1997).
Sheikh M.S.,et al.J. Biol. Chem. 272:26720-26726(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Yang C.,et al.J. Biol. Chem. 276:47277-47284(2001).
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