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Cathepsin K, Active, rat recombinant protein
CTSK, CTSO, CTSO3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O35186 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 23.5 kDa (115-329 aa) |
| Gene ID | 21975 |
|---|---|
| Gene Symbol | CTSK |
| Other Names | CTSK, CTSO, CTSO3 |
| Gene Source | Rat |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | The specific activity is >500 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit |
| Target/Specificity | Cathepsin K |
| Format | Liquid |
| Storage | -80°C; 0.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0) with 50% glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996).
References
Payne J.A.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
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