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TACE (TNF-α converting enzyme), human recombinant protein
Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P78536 |
|---|---|
| Calculated MW | 62 kDa |
| Gene ID | 6868 |
|---|---|
| Gene Symbol | ADAM17 |
| Other Names | Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme |
| Gene Source | Human |
| Source | Insect cell |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Application Notes | With sterile deionized water at 0.1 µg protein/ µl. |
| Format | Lyophilized powder |
| Storage | -70°C; The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form which is secreted. TACE is also known to process other membrane proteins including TNF receptor, TGF-alpha and amyloid protein precursor. Recombinant active untagged TACE amino acid sequence is from Arg215 to Asn651. The apparent molecular weight is bigger than the calculated MW due to the protein posttranslational modification in eukaryotic system.
References
Moss M.L.,et al.Nature 385:733-736(1997).
Black R.A.,et al.Nature 385:729-733(1997).
Patel I.R.,et al.J. Immunol. 160:4570-4579(1998).
Diaz-Rodriguez E.,et al.Mol. Biol. Cell 13:2031-2044(2002).
Thathiah A.,et al.J. Biol. Chem. 278:3386-3394(2003).
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