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TACE (TNF-α converting enzyme), human recombinant protein

Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme, CD156b

Product info
Primary Accession P78536
Calculated MW 62 kDa
Additional Info
Gene ID 6868
Gene Symbol ADAM17
Other Names Disintegrin and metalloproteinase domain-containing protein 17, ADAM 17, Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme
Gene Source Human
Source Insect cell
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Application Notes With sterile deionized water at 0.1 µg protein/ µl.
Format Lyophilized powder
Storage -70°C; The untagged rh-TACE (TNF-alpha converting enzyme) is supplied as a lyophilized powder.
Citations (0)

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TACE (TNF-alpha converting enzyme, ADAM17) is a membrane-bound Metalloprotease from the ADAM (a disintegrin and Metalloprotease) family of proteins. It cleaves 26kDa type II membrane-bound precursor of TNF-a into 17 kDa mature form which is secreted. TACE is also known to process other membrane proteins including TNF receptor, TGF-alpha and amyloid protein precursor. Recombinant active untagged TACE amino acid sequence is from Arg215 to Asn651. The apparent molecular weight is bigger than the calculated MW due to the protein posttranslational modification in eukaryotic system.


Moss M.L.,et al.Nature 385:733-736(1997).
Black R.A.,et al.Nature 385:729-733(1997).
Patel I.R.,et al.J. Immunol. 160:4570-4579(1998).
Diaz-Rodriguez E.,et al.Mol. Biol. Cell 13:2031-2044(2002).
Thathiah A.,et al.J. Biol. Chem. 278:3386-3394(2003).

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$ 295.00
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$ 5,950.00
Cat# PBV11210r-20
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