Granzyme B, Mouse recombinant protein (Insect)
GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte
|Calculated MW||33 kDa|
|Other Names||GranzymeB, Granzyme-2, T-cell serine protease 1-3E, Cytotoxic T-lymphocyte proteinase 2, Lymphocyte protease, SECT, Cathepsin G-like 1, CTSGL1, CTLA-1, Fragmentin-2, Human lymphocyte protein, HLP, C11|
|Application Notes||Use 50 µl sterile D.I. water to dissolve 5 µg protein to a final conc of 0.1 µg protein/ µl.|
|Storage||-70°C; rmGranzyme is supplied as a lyophilized powder|
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Provided below are standard protocols that you may find useful for product applications.
Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and enters the target cell, assisted by perforin. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell.
Lobe C.G.,et al.Science 232:858-861(1986).
Lobe C.G.,et al.Biochemistry 27:6941-6946(1988).
Brunet J.-F.,et al.Nature 322:268-271(1986).
Ko M.S.,et al.Mamm. Genome 5:349-355(1994).
Masson D.,et al.Cell 49:679-685(1987).
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