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Active recombinant protein Human beta-Secretase 1 - BACE-1
Beta-Secretase
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P56817 |
|---|---|
| Calculated MW | 47 kDa |
| Gene ID | 23621 |
|---|---|
| Gene Symbol | BACE1 |
| Other Names | Beta-secretase 1, Aspartyl protease 2, ASP2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, Aspartic-like protease 56 kDa, Aspartyl protease 1, Beta-site amyloid precursor protein cleaving enzyme 2, Down region aspartic protease, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase |
| Gene Source | Human |
| Source | Insect cell |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Application Notes | Use 20 µl sterile D.I. water to dissolve 10 µg of protein for a final conc of 0.5 µg/ µl. For further dilution, use 10 mM Tris, pH 8.0. |
| Format | Lyophilized powder |
| Storage | -70°C; Supplied as a lyophilized powder. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
β-Secretase, also called BACE1 (β-site of APP cleaving enzyme) or memapsin-2 is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. The transmembrane protein, contains two active site aspartate residues in its extracellular protein domain and may function as a dimer..
References
Vassar R.,et al.Science 286:735-741(1999).
Sinha S.,et al.Nature 402:537-540(1999).
Yan R.,et al.Nature 402:533-537(1999).
Hussain I.,et al.Mol. Cell. Neurosci. 14:419-427(1999).
Michel B.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
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