|Other Names||Histone deacetylase 3, HD3, RPD3-2, SMAP45|
|Source||Sf9 insect cells|
|Storage||-80°C; rh-HDAC-3 is supplied with N-term His-tag as a liquid in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
Human Histone Deacetylase 3 (HDAC3) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Like other class I and II HDAC members, the activity of HDAC3 is sensitive to HDAC inhibitor Trichostatin A (TSA).
Dangond F.,et al.Biochem. Biophys. Res. Commun. 242:648-652(1998).
Yang W.-M.,et al.J. Biol. Chem. 272:28001-28007(1997).
Emiliani S.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:2795-2800(1998).
Mahlknecht U.,et al.Genomics 56:197-202(1999).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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