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Sirtuin 2, human recombinant protein
Regulatory protein SIR2 homolog 2, SIR2-like protein 2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IXJ6 |
|---|---|
| Calculated MW | 43 kDa |
| Gene ID | 22933 |
|---|---|
| Gene Symbol | SIRT2 |
| Other Names | NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -70°C; rh-Sirtuin 2 (SIRT2) with the native N-terminus is supplied as a liquid of 2 mg/ml in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A.
References
Frye R.A.,et al.Biochem. Biophys. Res. Commun. 260:273-279(1999).
Afshar G.,et al.Gene 234:161-168(1999).
De Smet C.,et al.J. Neurochem. 81:575-588(2002).
Rack J.G.,et al.J. Mol. Biol. 426:1677-1691(2014).
Lennerz V.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
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