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Sirtuin 2, human recombinant protein

Regulatory protein SIR2 homolog 2, SIR2-like protein 2

     
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Product info
Primary Accession Q8IXJ6
Calculated MW 43 kDa
Additional Info
Gene ID 22933
Gene Symbol SIRT2
Other Names NAD-dependent protein deacetylase sirtuin-2, Regulatory protein SIR2 homolog 2, SIR2-like protein 2
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -70°C; rh-Sirtuin 2 (SIRT2) with the native N-terminus is supplied as a liquid of 2 mg/ml in 25 mM Tris, pH 7.5, 100 mM NaCl, 2.7 mM KCl, 3 mM MgCl2, 10 % glycerol.
Citations (0)

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Background

Human sirtuins function as intracellular regulatory proteins. Sirtuin 2 is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging. The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (0.1mM NAD+) dependent and insensitive to HDAC inhibitor trichostatin A.

References

Frye R.A.,et al.Biochem. Biophys. Res. Commun. 260:273-279(1999).
Afshar G.,et al.Gene 234:161-168(1999).
De Smet C.,et al.J. Neurochem. 81:575-588(2002).
Rack J.G.,et al.J. Mol. Biol. 426:1677-1691(2014).
Lennerz V.,et al.Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.

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$ 175.00
$ 375.00
$ 3,000.00
Cat# PBV11216r-20
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