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Bromodomain Testis-specific Protein (BrdT, domain 257-382 aa), human recombinant protein
Recombinant Human Bromodomain Testis-specific Protein (BrdT)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q58F21 |
|---|---|
| Calculated MW | 14.9 kDa (126 aa, 257-382 aa + NT His Tag) |
| Gene ID | 676 |
|---|---|
| Gene Symbol | BRDT |
| Other Names | BrdT, Cancer/testis antigen 9, CT9, RING3-like protein |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Target/Specificity | BRDT |
| Format | Liquid |
| Storage | -80°C; rh-BrdT is supplied as a solution in 50 mM Tris, pH 8.0, 150 mM NaCl and 10% Glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BrdT is similar to the RING3 protein family. It possesses 2 bromodomain motifs and a PEST sequence. The bromodomain is found in proteins that regulate transcription. BrdT drives a meiotic and post-meiotic gene expression program. It also controls the genome-wide post-meiotic genome reorganization that occurs after histone hyperacetylation in elongating spermatids. It may play a role in the transcriptional regulation of spermatogenesis. It also seems to have a structural ATP-independent role in the reorganization of acetylated chromatin. BioVision’s recombinant protein includes Bromo 1 domain (257-382 aa) with N-terminal His-tag.
References
Jones M.H.,et al.Genomics 45:529-534(1997).
Zheng Y.,et al.Int. J. Mol. Med. 15:315-321(2005).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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