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Bromodomain-containing Protein 4 (BrD4, domain 342-460 aa), human recombinant protein
Recombinant Human Bromodomain-containing Protein 4 (BrD4)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O60885 |
|---|---|
| Calculated MW | 12.4 kDa (119 aa, 342-460 aa + NT- His Tag) |
| Gene ID | 23476 |
|---|---|
| Gene Symbol | BRD4 |
| Other Names | BRD4, Protein HUNK1, HUNK1 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -80°C; rh-BrD4 is supplied as a solution in 50 mM Tris, pH 8.0, 150 mM NaCl and 10% Glycerol. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BrD4 protein is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. It plays a role in a process governing chromosomal dynamics during mitosis. BioVision's BrD4 recombinant protein includes Bromo 2 domain (342-460 aa) with a N-terminal His-tag.
References
French C.A.,et al.Am. J. Pathol. 159:1987-1992(2001).
Weber B.,et al.Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
French C.A.,et al.Cancer Res. 63:304-307(2003).
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