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>   home   >   Products   >   Proteins   >   BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant protein    

BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant protein

BRD4 bromodomains 1 and 2 (49-460 aa) (GST-tagged), Human recombinant

Product info
Primary Accession O60885
Calculated MW 73.4 kDa (49-460 aa + GST Tag)
Additional Info
Gene ID 23476
Gene Symbol BRD4
Other Names Bromodomain containing 4; HUNK1; MCAP
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity BRD4
Format Liquid
Storage -80°C; 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Citations (0)

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The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD2 and BRD4 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease.


French C.A.,et al.Am. J. Pathol. 159:1987-1992(2001).
Weber B.,et al.Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
French C.A.,et al.Cancer Res. 63:304-307(2003).

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$ 195.00
$ 685.00
Cat# PBV11227r
(40 western blots)
Availability: 5-7days
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