BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant protein
BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant
|Calculated MW||43.7 kDa (1367-1511 aa + NT GST Tag)|
|Other Names||SMARCA2A/B; SWI/SNF ATPase|
|Storage||-80°C; 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.|
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Provided below are standard protocols that you may find useful for product applications.
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.
Muchardt C.,et al.EMBO J. 12:4279-4290(1993).
Chiba H.,et al.Nucleic Acids Res. 22:1815-1820(1994).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kitagawa H.,et al.Cell 113:905-917(2003).
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