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TAF1 bromodomain 1 (1371-1496 aa) (GST-tagged), Human recombinant protein

TAF1 bromodomain 1 (1371-1496 aa) (GST-tagged), Human recombinant

Product info
Primary Accession P21675
Calculated MW 41.7 kDa (1371-1496 aa + NT GST Tag)
Additional Info
Gene ID 6872
Gene Symbol TAF1
Other Names TATA Box Binding Protein (TBP)-Associated Factor; KAT4; DYT3; CCGS; NSCL2; XDP; TAF1 RNA Polymerase II; TAF2A; TAFII250; BA2R; CCG1
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity TAF1
Format Liquid
Storage -80°C; 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
Citations (0)

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The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. TAF1 is a component of transcription factor IID, and binds to core promoter sequences at the transcription start site. TAF1 helps control transcription by both its kinase and histone acetyltransferase enzymatic activities. It interacts with transcriptional activators such as the androgen receptor to promote transcription. Disruption of TAF1 causes dystonia 3 (X-linked torsion dystonia) and decreased apoptosis. This protein product contains the first bromodomain of TAF1.


Sekiguchi T.,et al.Mol. Cell. Biol. 11:3317-3325(1991).
Sekiguchi T.,et al.EMBO J. 7:1683-1687(1988).
Ruppert S.,et al.Nature 362:175-179(1993).
Makino S.,et al.Am. J. Hum. Genet. 80:393-406(2007).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 175.00
$ 595.00
Cat# PBV11236r-20
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