|Calculated MW||53.5 kDa (1- 441 aa + NT His Tag)|
|Other Names||Embryonic Ectoderm Development|
|Source||Insect (SF21) cells (baculovirus expression system)|
|Storage||-80°C; 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.|
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Polycomb protein Embryonic Ectoderm Development (EED) is a WD repeat containing member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.
Schumacher A.,et al.Genomics 54:79-88(1998).
Sewalt R.G.A.B.,et al.Mol. Cell. Biol. 18:3586-3595(1998).
Peytavi R.,et al.J. Biol. Chem. 274:1635-1645(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
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