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Histone H4 (1-103 aa), Human recombinant protein

Histone H4 (1-103 aa), Human recombinant

Product info
Primary Accession P62805
Calculated MW 11.5 kDa (1-136 aa)
Additional Info
Gene ID 8359
Gene Symbol HIST1H4A
Other Names Histone H4, H4
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Histone H4
Application Notes Resuspend in buffer of choice.
Format Lyophilized powder
Storage -80°C; Lyophilized powder. Recommended buffer is 50 mM NaPO₄ containing 100 mM sodium chloride and 20% glycerol.
Citations (0)

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H2A is a core component of nucleosome. A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around an octamer of histones. The octamer is composed of two of each histone H2A, H2B, H3, and H4. DNA accessibility is regulated via a complex set of post-translational modifications of these histones, also called histone code, and nucleosome remodeling. Histones H2A and H2B form a dimer. Histones H3 and H4 form a tetramer. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Histone H4 undergoes many modifications which include acetylation, phosphorylation and methylation that are important for regulation of gene transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability.


Sierra F.,et al.Nucleic Acids Res. 11:7069-7086(1983).
Pauli U.,et al.Science 236:1308-1311(1987).
Albig W.,et al.Genomics 10:940-948(1991).
Drabent B.,et al.DNA Cell Biol. 14:591-597(1995).
Albig W.,et al.Gene 184:141-148(1997).

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$ 165.00
$ 365.00
Cat# PBV11247r
(40 western blots)
Availability: 5-7days
Bulk Size
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