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SIRT4 (GST-tagged), Human recombinant protein

SIRT4 (GST-tagged), Human recombinant

Product info
Primary Accession Q9Y6E7
Calculated MW 61.9 kDa (NT GST Tag)
Additional Info
Gene ID 23409
Gene Symbol SIRT4
Other Names SIR2-like Protein 4; NAD-dependent ADP-ribosyltransferase Sirtuin 4; SIR2L4; Silent Information Regulator 4; Sirtuin 4
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity SIRT4
Format Liquid
Storage -80°C; 50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, 2.5 mM DTT, 20% glycerol.
Citations (0)

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There are seven human sirtuins, also known as class III HDACs, which have been designated SIRT1 to SIRT7. Each is involved in various post-translational modifications by utilizing NAD dependent deacetylase and APD-ribosyltransferase activities. SIRT4 is a mitochondrial ADP-ribosyltransferase responsible for the transfer of ADP-ribose from NAD to specific substrates such as glutamate dehydrogenase (GDH). In caloric-sufficient conditions, SIRT4 ADP-ribosylates GDH, repressing its activity and correspondingly decreasing insulin secretion. There is some uncertainty about the relevance of sirtuin ribosyl transferase activity due to its very slow rate, which is about 500 times lower than the corresponding deacetylation reaction (for those that have been characterized). SIRT4 is found in many tissues, but is specifically enriched in the kidney, heart, brain, and liver.


Frye R.A.,et al.Biochem. Biophys. Res. Commun. 260:273-279(1999).
Scherer S.E.,et al.Nature 440:346-351(2006).
Haigis M.C.,et al.Cell 126:941-954(2006).
Ahuja N.,et al.J. Biol. Chem. 282:33583-33592(2007).
Michishita E.,et al.Mol. Biol. Cell 16:4623-4635(2005).

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$ 135.00
$ 275.00
Cat# PBV11249r-20
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