SIRT7 (2-400 aa) (His-tagged), Human recombinant protein
SIRT7 (2-400 aa) (His-tagged), Human recombinant
|Calculated MW||49.3 kDa (2-400 aa, NT His Tag)|
|Other Names||NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7|
|Storage||-80°C; 50 mM sodium phosphate, pH 7.2, 100 mM sodium chloride, 5 mM DTT, and 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
de Nigris F.,et al.Br. J. Cancer 86:917-923(2002).
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