JMJD6 (2-403 aa) (GST-tagged), Human recombinant protein
JMJD6 (2-403 aa) (GST-tagged), Human recombinant
|Calculated MW||73.2 kDa (2-403 aa, NT GST Tag)|
|Other Names||KIAA0585; Jumonji Domain Containing 6; PTDSR1|
|Storage||-80°C; 50 mM HEPES, pH 7.4, containing 150 mM sodium chloride.|
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JMJD6 is a member of the Jumonji C (JmjC)-domain family. This family consists of α-ketoglutarate dependent enzymes which use a cupin fold to coordinate an iron atom. JMJD6 was initially proposed to function as a histone arginine demethylase. Further studies suggest that JMJD6 has hydroxylase activity towards histone tails, the splicing regulatory protein LUC7-Like2, or single-stranded RNA. Recent evidence suggests that JMJD6 gene expression may be a biomarker for aggressive breast cancers.
Izawa M.,et al.Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 5:31-39(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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