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Prothrombin, Human Plasma recombinant protein

Coagulation factor II

Product info
Primary Accession P00734
Calculated MW 72 kDa
Additional Info
Gene ID 2147
Gene Symbol F2
Other Names Coagulation factor II
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Target/Specificity Prothrombin
Format Liquid
Storage -80°C; In 20 mM Tris-HCl, 0.1 M NaCl pH 7.4
Citations (0)

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Prothrombin is a vitamin K-dependent plasma protein which is synthesized in the liver. Prior to secretion into plasma, prothrombin undergoes post-translational modification by a vitamin K-dependent carboxylase which converts ten specific glutamic acid residues to γ-carboxyglutamic acid (gla). Conversion to thrombin is a key step in the blood coagulation pathway and catalyzes the coagulation of fibrinogen. Clinically, cases of selective deficiency are rare, although, in cases of liver cirrhosis, prothrombin is decreased. During activation, prothrombin is cleaved at Arg271-Thr272 and at Arg320-Ser321 to a "pro" fragment (fragment 1.2) and thrombin, the latter of which is composed of two chains covalently linked by a disulfide bond. There is an additional thrombin feed-back cleavage at Arg284-Thr285 resulting in an additional 13 amino acids being removed from the mature thrombin “A” chain.


Degen S.J.F.,et al.Biochemistry 26:6165-6177(1987).
Wang W.,et al.Haemophilia 10:94-97(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Degen S.J.F.,et al.Biochemistry 22:2087-2097(1983).

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$ 115.00
Cat# PBV11260r
(40 western blots)
Availability: 5-7days
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