Prekallikrein, Human Plasma recombinant protein
Fletcher factor, Kininogenin.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P03952 |
---|---|
Calculated MW | 86 kDa |
Gene ID | 3818 |
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Gene Symbol | KLK |
Other Names | Fletcher factor, Kininogenin. |
Gene Source | Human |
Source | Human Plasma |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | N/A; |
Recombinant | No |
Results | Lot dependent |
Target/Specificity | Prekallikrein |
Format | Liquid |
Storage | -80°C; In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Prekallikrein is the glycosylated single chain zymogen precursor of the plasma serine protease kallikrein. Plasma prekallikrein circulates with kininogen and is activated by Factor XIIa in the intrinsic coagulation pathway. Kallikrein activates plasminogen in fibrinolysis and cleaves kininogen in the bradykinin system of vasodilation. Prekallikrein deficiency is rare and causes increased activated partial thromboplastin time. Elevated plasma prekallikrein is associated with diabetes and cardiovascular disease.
References
Chung D.W.,et al.Biochemistry 25:2410-2417(1986).
Yu H.,et al.Genomics 69:225-234(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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