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Factor VIIa, Human Plasma recombinant protein
Proconvertin, Serum prothrombin conversion accelerator.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08709 |
|---|---|
| Calculated MW | 50 kDa |
| Gene ID | 2155 |
|---|---|
| Gene Symbol | F7 |
| Other Names | Proconvertin, Serum prothrombin conversion accelerator. |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Results | Lot dependent |
| Target/Specificity | Factor VIIa |
| Format | Liquid |
| Storage | -80°C; In 20 mM Tris-HCl, 0.1 M NaCl pH 7.4 |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Human factor VII is a single chain plasma glycoprotein, and is a zymogen in its native form. Proteolytic activation of factor VII, yields the enzyme factor VIIa, which when bound to the integral membrane protein tissue factor, forms an enzyme complex that proteolytically converts factor X to factor Xa. This enzyme complex is best known as the extrinsic factor Xase (pronounced ten-ase) complex, since by virtue of its tissue factor component, it is composed of protein normally extrinsic to the plasma environment. The conversion of factor VII to factor VIIa is catalyzed by a number of proteases including thrombin, factor IXa, factor Xa, factor XIa, and factor XIIa. Rapid activation also takes place when factor VII is combined with tissue factor in the presence of calcium.
References
Hagen F.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:2412-2416(1986).
O'Hara P.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5158-5162(1987).
Sabater-Lleal M.,et al.Hum. Genet. 118:741-751(2006).
Soria J.M.,et al.Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
Masroori N.,et al.Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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