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Factor X, Human Plasma recombinant protein

Stuart factor, Stuart-Prower factor

     
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Product info
Primary Accession P00742
Calculated MW 58.8 kDa
Additional Info
Gene ID 2159
Gene Symbol F10
Other Names Stuart factor, Stuart-Prower factor
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Results Lot dependent
Target/Specificity Factor X
Format Liquid
Storage -80°C; In 20 mM Tris-HCl, 0.1 M NaCl, 1 mM Benzamidine pH 7.4.
Citations (0)

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Background

Factor X is a vitamin K-dependent protein zymogen which is synthesized in the liver and circulates in plasma as a two chain molecule linked by a disulfide bond. Prior to secretion into plasma, post-translational modifications produce 11 gamma-carboxyglutamic acid (gla) residues and a single b-hydroxyaspartic acid residue, which are located within the NH2-terminal light chain. The light chain also contains two epidermal growth factor (EGF) homology domains. The COOH-terminal heavy chain of factor X contains most of the carbohydrate moieties, as well as the latent serine protease domain. The activation of factor X is catalyzed by either the intrinsic factor Xase complex (factor IXa, factor VIIIa, cellular surface and calcium ions) or the extrinsic factor Xase complex (factor VIIa, tissue factor, cellular surface and calcium ions).

References

Messier T.L.,et al.Gene 99:291-294(1991).
Leytus S.P.,et al.Biochemistry 25:5098-5102(1986).
Fung M.R.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:3591-3595(1985).
Kaul R.K.,et al.Gene 41:311-314(1986).
McMullen B.A.,et al.Biochemistry 22:2875-2884(1983).

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$ 275.00
Cat# PBV11264r
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