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Factor XII, Human Plasma
Stuart factor, Stuart-Prower factor
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00748 |
|---|---|
| Calculated MW | 80.00 kDa |
| Gene ID | 2161 |
|---|---|
| Gene Symbol | F12 |
| Other Names | Stuart factor, Stuart-Prower factor |
| Gene Source | Human |
| Source | Human Plasma |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | N/A; |
| Recombinant | No |
| Results | Lot dependent |
| Target/Specificity | Factor XII |
| Format | Liquid |
| Storage | -80°C; In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Factor XII is a single chain glycoprotein with a molecular weight of about 80,000. Once activated, principally from the action of kallikrein, Factor XII is converted into an active serine protease (Factor α-Xlla) that functions in the in vivo initiation of blood coagulation, fibrinolysis, and kinin formation. Human Factor XII has been purified by ion exchange chromatography.
References
Cool D.E.,et al.J. Biol. Chem. 262:13662-13673(1987).
Schmutz J.,et al.Nature 431:268-274(2004).
Tripodi M.,et al.Nucleic Acids Res. 14:3146-3146(1986).
Cool D.E.,et al.J. Biol. Chem. 260:13666-13676(1985).
Que B.G.,et al.Biochemistry 25:1525-1528(1986).
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