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Factor XIIa, Human Plasma recombinant protein

Hageman factor

Product info
Primary Accession P00748
Calculated MW 80.00 kDa
Additional Info
Gene ID 2161
Gene Symbol F12
Other Names Hageman factor
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Results Lot dependent
Target/Specificity Factor XIIa
Format Liquid
Storage -80°C; In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3.
Citations (0)

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Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade.


Cool D.E.,et al.J. Biol. Chem. 262:13662-13673(1987).
Schmutz J.,et al.Nature 431:268-274(2004).
Tripodi M.,et al.Nucleic Acids Res. 14:3146-3146(1986).
Cool D.E.,et al.J. Biol. Chem. 260:13666-13676(1985).
Que B.G.,et al.Biochemistry 25:1525-1528(1986).

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$ 315.00
Cat# PBV11267r
(40 western blots)
Availability: 5-7days
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