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>   home   >   Products   >   Proteins   >   Fibrinogen (Pg, Fn & vWF depleted), Human Plasma recombinant protein   

Fibrinogen (Pg, Fn & vWF depleted), Human Plasma recombinant protein

Factor 1

Product info
Primary Accession P02671
Calculated MW 330.00 kDa
Additional Info
Gene ID 2243
Gene Symbol FGA
Other Names Factor 1
Gene Source Human
Source Human Plasma
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant No
Results > 95% clottable by functional assays
Target/Specificity Fibrinogen
Format Liquid
Storage -80°C; In 20 mM Sodium Citrate-HCl pH 7.4.
Citations (0)

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Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolysis fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.


Fu Y.,et al.Biochemistry 31:11968-11972(1992).
Chung D.W.,et al.(In) Ebert R.F. (eds.);
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Chung D.W.,et al.Adv. Exp. Med. Biol. 281:39-48(1990).

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$ 120.00
Cat# PBV11270r
(40 western blots)
Availability: 5-7days
Bulk Size
Seasonal Special on Bulk Order
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