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Active SIRT6 (GST-tagged), human recombinant protein

SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein

Product info
Primary Accession Q8N6T7
Concentration 1
Calculated MW Human SIRT6 is a 65.3 kDa (1-355 aa + N-terminal GST tag) protein. It runs as ~62 kDa on a SDS-PAGE.
Additional Info
Gene ID 51548
Gene Symbol SIRT6
Other Names SIRT6, NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥85%
Assay2&Purity2 HPLC;
Recombinant Yes
Results >3 mU/mg
Target/Specificity SIRT6
Format Liquid
Storage -80°C; Human SIRT6 protein is a solution of 1 mg/ml in 50 mM Tris, 100 mM NaCl, pH 8.0 containing 20% glycerol.
Citations (0)

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Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards Lys-9 and Lys-56 of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-α.


Frye R.A.,et al.Biochem. Biophys. Res. Commun. 273:793-798(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Grimwood J.,et al.Nature 428:529-535(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

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$ 195.00
$ 375.00
$ 2,595.00
Cat# PBV11273r
(40 western blots)
Availability: 5-7days
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