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>   home   >   Products   >   Proteins   >   Active Transglutaminase 2 (His-tagged), human recombinant protein   

Active Transglutaminase 2 (His-tagged), human recombinant protein

TG2, tTG, tissue transglutaminase, transglutaminase C, TGC, protein-glutamine-gamma-glutamyltransfer

Product info
Primary Accession P21980
Calculated MW 79.5 kDa (1-687 aa + N-terminal polyhistidine tag).
Additional Info
Gene ID 7052
Gene Symbol TGM2
Other Names TG2, tTG, tissue transglutaminase, transglutaminase C, TGC, protein-glutamine-gamma-glutamyltransferase, TGM2
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Results >400 mU/mg
Sequence 1-687 aa of human transglutaminase 2 + N-terminal polyhistidine tag
Target/Specificity Transglutaminase 2
Application Notes Reconstitute to 0.1-0.5 mU/ µl in 20 mM Tris, 120 mM NaCl, 10 mM DTT, pH 7.5 containing 20% glycerol. Aliquot and store at –80°C. Avoid repeated freezing and thawing cycles.
Format Lyophilized powder
Storage -80°C; Lyophilized from 5 mg/ml solution in a proprietary buffer.
Citations (0)

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Tissue transglutaminase, a 78-kDa calcium dependent enzyme (EC, is found both in the intracellular and the extracellular spaces of various types of tissues. TG2 crosslinks proteins between the ε-amino group of a lysine residue and the γ-carboxamide group of glutamine residue, creating an inter- or intramolecular bond that is highly resistant to proteolysis (protein degradation). TG2 also possesses deamidation, GTP-binding/hydrolyzing, and isopeptidase activities. Intracellular TG2 is thought to play an important role in apoptosis, while extracellular TG2 has been linked to cell adhesion, ECM stabilization, wound healing, receptor signaling, cellular proliferation, and cellular motility.


Gentile V.,et al.J. Biol. Chem. 266:478-483(1991).
Fraij B.M.,et al.J. Biol. Chem. 267:22616-22623(1992).
Fraij B.M.,et al.Biochim. Biophys. Acta 1306:63-74(1996).
Bayardo M.P.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 169.00
$ 499.00
Cat# PBV11276r
(40 western blots)
Availability: 5-7days
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