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PIM2, Active recombinant protein

PIM, Serine/threonine-protein kinase Pim-2

     
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  • CITATIONS
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Product info
Primary Accession Q9P1W9
Concentration 0.1
Calculated MW 61.0 kDa
Additional Info
Gene ID 11040
Gene Symbol PIM2
Other Names PIM, Serine/threonine-protein kinase Pim-2
Source Baculovirus (Sf9 insect cells)
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -80°C; Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Citations (0)
citation

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Background

Baytel et al. identified a deduced 334-amino acid sequence of the clone, which showed 90% identity with the mouse Pim2 protein. Like mouse Pim2, the human protein appears to be a serine threonine kinase. Northern blot analysis detected 2 PIM2 transcripts in all tissues tested, but most abundantly in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It was also highly expressed in human leukemic and lymphoma cell lines and a colorectal adenocarcinoma cell line. The results suggested a role for PIM2 in proliferating cells as well as during meiosis (1). Yan et al investigated potential functions for the pim family of kinases in factor-dependent murine hematopoietic cells and indicate that pim-2 functions similarly to pim-1 as a pro-survival kinase and suggest that BAD is a legitimate PIM-2 substrate (2). Hammerman et al concluded that the transcriptional induction of Pim-2 initiated a novel NF-kappaB activation pathway that regulates cell survival (3).

References

Baytel D.,et al.Biochim. Biophys. Acta 1442:274-285(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Ishida N.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Ross M.T.,et al.Nature 434:325-337(2005).
Leong W.F.,et al.Cell. Microbiol. 8:565-580(2006).

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Discontinued
Cat# PBV11306r-5
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