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BMX, Active recombinant protein

BMX, Cytoplasmic tyrosine-protein kinase BMX

     
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Product info
Primary Accession P51813
Concentration 0.1
Calculated MW 110.0 kDa
Additional Info
Gene ID 660
Gene Symbol BMX
Other Names BMX, Cytoplasmic tyrosine-protein kinase BMX, Bone marrow tyrosine kinase gene in chromosome X protein, Epithelial and endothelial tyrosine kinase, NTK38
Source Baculovirus (Sf9 insect cells)
Assay&Purity SDS-PAGE; ≥80%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -80°C; Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Citations (0)

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Background

The BMX gene encodes a novel non receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells (1). Bmx cDNA comprises a long open reading frame of 675 amino acids, containing one SH3, one SH2 and one tyrosine kinase domain, which are about 70% identical with Btk, Itk and Tec and somewhat less with Txk tyrosine kinase sequences. The amino terminal sequences of these four tyrosine kinases are about 40% identical and each contains a so-called pleckstrin homology (PH) domain. The 2.7 kb Bmx mRNA is expressed in endothelial cells and several human tissues by Northern blotting and an 80 kD Bmx polypeptide was detected in human endothelial cells. The BMX gene is located in chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked aγglobulinemia. Bmx, is found to induce activation of the Stat signaling pathway (3). Bmx induced the tyrosine phosphorylation and DNA binding activity of all the Stat factors tested, including Stat1, Stat3, and Stat5, both in mammalian and insect cells. Bmx also induced transcriptional activation of Stat1- and Stat5-dependent reporter genes.

References

Tamagnone L.,et al.Oncogene 9:3683-3688(1994).
Qiu Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:3644-3649(1998).
Ross M.T.,et al.Nature 434:325-337(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Nore B.F.,et al.Biochim. Biophys. Acta 1645:123-132(2003).

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$ 295.00
Cat# PBV11308r
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(40 western blots)
Availability: 5-7days
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