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SGK1, Active recombinant protein

SGK, serum/glucocorticoid regulated kinase 1

Product info
Primary Accession O00141
Concentration 0.1
Calculated MW 73.0 kDa
Additional Info
Gene ID 6446
Gene Symbol SGK1
Other Names SGK, serum/glucocorticoid regulated kinase 1
Source Baculovirus (Sf9 insect cells)
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 HPLC;
Recombinant Yes
Format Liquid
Storage -80°C; Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Citations (0)

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SGK1 is a member of the serum- and glucocorticoid-induced protein kinase that is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol (PI) 3-kinase (1). SGK1, mRNA is expressed in all tissues and the levels of SGK1 mRNA is increased by stimulation with serum or dexamethasone. SGK1 promotes cell survival by phosphorylating and inactivating FKHRL1. SGK and Akt display differences with respect to the efficacy with which they phosphorylate the three regulatory sites on FKHRL1. While both kinases can phosphorylate Thr-32, SGK1 displays a marked preference for Ser-315 whereas Akt favors Ser-253. These findings suggest that SGK1 and Akt may coordinately regulate the function of FKHRL1 by phosphorylating this transcription factor at distinct sites. Like PKB, SGK1 preferentially phosphorylate Ser and Thr residues that lie in Arg-Xaa-Arg-Xaa-Xaa-Ser/Thr motifs. SGK1 gene has recently been identified as an important aldosterone-induced protein kinase that mediates trafficking of the renal epithelial Na(+) channel (ENaC) to the cell membrane. Thus, SGK1 is an appealing candidate for blood pressure regulation and possibly essential hypertension (3).


Waldegger S.,et al.Proc. Natl. Acad. Sci. U.S.A. 94:4440-4445(1997).
Waldegger S.,et al.Genomics 51:299-302(1998).
Raikwar N.S.,et al.Am. J. Physiol. 295:F1440-F1448(2008).
Hall B.A.,et al.Submitted (AUG-2008) to the EMBL/GenBank/DDBJ databases.
Kim M.K.,et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
Cat# PBV11323r
(40 western blots)
Availability: 5-7days
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