|Calculated MW||86.0 kDa|
|Other Names||PI3K (p85⍺) Protein, PI3K, PI3 kinase|
|Source||Baculovirus (Sf9 insect cells)|
|Storage||-80°C; Recombinant protein in storage buffer (50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 2 mM DTT, 150 mM imidazole, 0.1 mM PMSF, 25 % glycerol.).|
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Provided below are standard protocols that you may find useful for product applications.
The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. p85αmodulates the interaction between PI3K and platelet-derived growth factor receptor (1). Furthermore, estrogen receptor isoform ER-alpha binds in a ligand-dependent manner to the p85α regulatory subunit of PI3K. Stimulation with estrogen increases ER-alpha-associated PI3K activity, leading to the activation of protein kinase B/AKT and endothelial nitric oxide synthase (eNOS) (2).
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