|Calculated MW||76.5 kDa|
|Other Names||Heat shock protein 75 kDa, HSP 75, TNFR-associated protein 1, Tumor necrosis factor type 1 receptor-associated protein, TRAP-1|
|Storage||-80°C; 50 mM potassium phosphate pH 7.4, 50 mM sodium chloride, 0.5 mM DTT, 0.5 mM EDTA, and 2.5% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
Human TRAP1 belongs to the mitochondrial heat shock protein family. These molecular chaperones are highly conserved and play an important role in signal transduction, protein folding and degradation. Recombinant human TRAP1 has a C-terminal FLAG tag and has 702 amino acid residues. It has been identified to be protective for cell survival, and has been suggested as a target for anti-cancer therapeutics. Also can be useful for studies including enzyme kinetics, activator screening and selectivity profiling.
Simmons A.D.,et al.Hum. Mol. Genet. 8:2155-2164(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Martin J.,et al.Nature 432:988-994(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Song H.Y.,et al.J. Biol. Chem. 270:3574-3581(1995).
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