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TIMP-1, human neutrophil granulocytes recombinant protein
Tissue Inhibitor of Matrix Metalloproteinases – 1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P01033 |
|---|---|
| Calculated MW | 28.0 kDa |
| Gene ID | 7076 |
|---|---|
| Gene Symbol | TIMP1 |
| Other Names | Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1) |
| Gene Source | Human |
| Source | Human neutrophil granulocytes (Buffy Coat) |
| Assay&Purity | SDS-PAGE; ≥92% |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Format | Liquid |
| Storage | -80°C; In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 µM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃ |
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Provided below are standard protocols that you may find useful for product applications.
Background
The tissue inhibitor of metalloproteinases (TIMP-1) is a glycoprotein with a molecular mass of about 28-kDa. The secreted protein consists of 184 amino acids, six disuilfide bonds and two glycosylation sites containing N-linked oligosaccharides. TIMP-1 specifically inhibits the extracellular-matrix-egradingmetalloproteinases such as collagenase, gelatinase and stromelysin. It has no activity on mammalian membrane metallo-proteinases, procollagen peptidase, or on bacterial metalloproteinases such as thermolysin
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