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GDA, human recombinant protein
Guanine deaminase, CYPIN, GUANASE, NEDASIN
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9Y2T3 |
|---|---|
| Concentration | 1 |
| Calculated MW | 53 kDa (477 aa, 1-454 aa + His Tag) |
| Gene ID | 9615 |
|---|---|
| Gene Symbol | GDA |
| Other Names | Guanine deaminase, CYPIN, GUANASE, NEDASIN |
| Gene Source | Human |
| Source | E.coli |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Results | Specific activity is > 0.9 unit/ml |
| Sequence | MGSSHHHHHH SSGLVPRGSH MGSMCAAQMP PLAHIFRGTF VHSTWTCPME VLRDHLLGVS DSGKIVFLEE ASQQEKLAKE WCFKPCEIRE LSHHEFFMPG LVDTHIHASQ YSFAGSSIDL PLLEWLTKYT FPAEHRFQNI DFAEEVYTRV VRRTLKNGTT TACYFATIHT DSSLLLADIT DKFGQRAFVG KVCMDLNDTF PEYKETTEES IKETERFVSE MLQKNYSRVK PIVTPRFSLS CSETLMGELG NIAKTRDLHI QSHISENRDE VEAVKNLYPS YKNYTSVYDK NNLLTNKTVM AHGCYLSAEE LNVFHERGAS IAHCPNSNLS LSSGFLNVLE VLKHEVKIGL GTDVAGGYSY SMLDAIRRAV MVSNILLINK VNEKSLTLKE VFRLATLGGS QALGLDGEIG NFEVGKEFDA ILINPKASDS PIDLFYGDFF GDISEAVIQK FLYLGDDRNI EEVYVGGKQV VPFSSSV |
| Target/Specificity | GDA |
| Format | Liquid |
| Storage | -20°C; 1 mg/ml solution 20 mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1 mM DTT. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GDA is an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human GDA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
References
Yuan G.,et al.J. Biol. Chem. 274:8175-8180(1999).
Kuwahara H.,et al.J. Biol. Chem. 274:32204-32214(1999).
Park K.H.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
Nagase T.,et al.DNA Res. 6:337-345(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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