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>   home   >   Products   >   Proteins   >   PPM1F, human recombinant protein    

PPM1F, human recombinant protein

Protein phosphatase 1F, CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2

     
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Product info
Primary Accession P49593
Concentration 1
Calculated MW 52 kDa (477 aa, 1-454 aa + His Tag)
Additional Info
Gene ID 9647
Gene Symbol PPM1F
Other Names Protein phosphatase 1F, CAMKP, CaMKPase, FEM-2, hFEM-2, POPX2
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity is > 1200 unit/mg
Sequence MGSSHHHHHH SSGLVPRGSH MGSMSSGAPQ KSSPMASGAE ETPGFLDTLL QDFPALLNPE DPLPWKAPGT VLSQEEVEGE LAELAMGFLG SRKAPPPLAA ALAHEAVSQL LQTDLSEFRK LPREEEEEEE DDDEEEKAPV TLLDAQSLAQ SFFNRLWEVA GQWQKQVPLA ARASQRQWLV SIHAIRNTRR KMEDRHVSLP SFNQLFGLSD PVNRAYFAVF DGHGGVDAAR YAAVHVHTNA ARQPELPTDP EGALREAFRR TDQMFLRKAK RERLQSGTTG VCALIAGATL HVAWLGDSQV ILVQQGQVVK LMEPHRPERQ DEKARIEALG GFVSHMDCWR VNGTLAVSRA IGDVFQKPYV
Target/Specificity PPM1F
Format Liquid
Storage -20°C; 1 mg/ml solution 20 mM Tris-HCl buffer (pH 8.0), 20% glycerol, 150 mM NaCl and 1 mM DTT.
Citations (0)

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Background

PPM1F is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. Recombinant human PPM1F protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Tan K.M.L.,et al.J. Biol. Chem. 276:44193-44202(2001).
Koh C.-G.,et al.Curr. Biol. 12:317-321(2002).
Nomura N.,et al.DNA Res. 1:27-35(1994).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Dunham I.,et al.Nature 402:489-495(1999).

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$ 295.00
Cat# PBV11369r-100
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