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NMNAT2, human recombinant protein

Nicotinamide mononucleotide Adenylyltransferase 2, C1orf15, PNAT2

     
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Product info
Primary Accession Q9BZQ4
Concentration 0.25
Calculated MW 36.6 kDa (327 aa, 1-307 aa + His Tag)
Additional Info
Gene ID 23057
Gene Symbol NMNAT2
Other Names Nicotinamide mononucleotide Adenylyltransferase 2, C1orf15, PNAT2
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥85%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity: > 500 pmol/min/ µg
Sequence MGSSHHHHHH SSGLVPRGSH MTETTKTHVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL VSSRHRLIMC QLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP SMTPVIGQPQ NETPQPIYQN SNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA NLGTVMRYEE IELRILLLCG SDLLESFCIP GLWNEADMEV IVGDFGIVVV PRDAADTDRI MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHG DGHVVDYLSQ PVIDYILKSQ LYINASG
Target/Specificity NMNAT2
Format Liquid
Storage -20°C; 0.25 mg/ml solution 20 mM Tris-HCl buffer (pH 8.0), 20% glycerol, 150 mM NaCl and 1 mM DTT.
Citations (0)

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Background

NMNAT2 belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. Recombinant human NMNAT2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Sood R.,et al.Genomics 73:211-222(2001).
Seki N.,et al.DNA Res. 4:345-349(1997).
Gregory S.G.,et al.Nature 441:315-321(2006).
Raffaelli N.,et al.Biochem. Biophys. Res. Commun. 297:835-840(2002).
Yalowitz J.A.,et al.Biochem. J. 377:317-326(2004).

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$ 275.00
$ 395.00
Cat# PBV11370r
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