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IMPAD1, human recombinant protein

Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3

     
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Product info
Primary Accession Q9NX62
Concentration 0.25
Calculated MW 37.6 kDa (349 aa, 34-359 aa + His Tag)
Additional Info
Gene ID 54928
Gene Symbol IMPAD1
Other Names Inositol monophosphatase 3, GPAPP, IMP 3, IMP-3, IMPA3
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity > 3300 pmole/min/ µg
Sequence MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK
Target/Specificity IMPAD1
Format Liquid
Storage -20°C; 0.25 mg/ml solution in PBS (pH 7.4).
Citations (0)

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Background

IMPAD1, also known as Inositol monophosphatase 3, is a member of the inositol monophosphatase family. IMPAD1 is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. Recombinant human IMPAD1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

References

Parthasarathy L.,et al.Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Frederick J.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:11605-11612(2008).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Van Damme P.,et al.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).

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$ 295.00
Cat# PBV11371r
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