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PTPN7, human recombinant protein

Tyrosine-protein phosphatase non-receptor type 7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI

     
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Product info
Primary Accession P35236
Concentration 0.5
Calculated MW 43.1 kDa (384 aa, 1-360 aa + His Tag)
Additional Info
Gene ID 5778
Gene Symbol PTPN7
Other Names Tyrosine-protein phosphatase non-receptor type 7, BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity is > 2000 unit/mg
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMVQAHG GRSRAQPLTL SLGAAMTQPP PEKTPAKKHV RLQERRGSNV ALMLDVRSLG AVEPICSVNT PREVTLHFLR TAGHPLTRWA LQRQPPSPKQ LEEEFLKIPS NFVSPEDLDI PGHASKDRYK TILPNPQSRV CLGRAQSQED GDYINANYIR GYDGKEKVYI ATQGPMPNTV SDFWEMVWQE EVSLIVMLTQ LREGKEKCVH YWPTEEETYG PFQIRIQDMK ECPEYTVRQL TIQYQEERRS VKHILFSAWP DHQTPESAGP LLRLVAEVEE SPETAAHPGP IVVHCSAGIG RTGCFIATRI GCQQLKARGE VDILGIVCQL RLDRGGMIQT AEQYQFLHHT LALYAGQLPE EPSP
Target/Specificity PTPN7
Format Liquid
Storage -20°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 M NaCl and 1 mM DTT
Citations (0)

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Background

PTPN7, also known as tyrosine-protein phosphatase non-receptor type 7 isoform 1, acts preferentially on tyrosine-phosphorylated MAPK1. This protein plays a role in the regulation of T and B-lymphocyte development and signal transduction. Recombinant human PTPN7 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

References

Adachi M.,et al.Biochem. Biophys. Res. Commun. 186:1607-1615(1992).
Zanke B.,et al.Eur. J. Immunol. 22:235-239(1992).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 295.00
Cat# PBV11372r
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