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DUSP18, human recombinant protein

Dual specificity protein phosphatase 18, DUSP20

     
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Product info
Primary Accession Q8NEJ0
Concentration 0.5
Calculated MW 40.4 kDa (359 aa, 149-482 aa + His Tag)
Additional Info
Gene ID 150290 
Gene Symbol DUSP18
Other Names Dual specificity protein phosphatase 18, DUSP20
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity: >1,100 units/mg
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMTAPSC AFPVQFRQPS VSGLSQITKS LYISNGVAAN NKLMLSSNQI TMVINVSVEV VNTLYEDIQY MQVPVADSPN SRLCDFFDPI ADHIHSVEMK QGRTLLHCAA GVSRSAALCL AYLMKYHAMS LLDAHTWTKS CRPIIRPNSG FWEQLIHYEF QLFGKNTVHM VSSPVGMIPD IYEKEVRLMI PL
Target/Specificity DUSP18
Format Liquid
Storage -20°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.1 mM PMSF, 1 mM EDTA and 1 mM DTT
Citations (0)

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Background

Dual specificity phosphatase 18, also known as DuSP18, is a member of the dual-specificity phosphatase (DSP) family, which catalyzes dephosphorylation of phosphotyrosine and phosphothreonine residues. DuSP18 is inhibited by iodoarectic acid and is activated by manganese ions. Along with having preferential enzymatic activity against phosphorylated tyrosine residues over threonine residues, DuSP18 also dephosphorylates p-nitrophenyl phosphate (pNPP) in vitro. This protein is widely expressed with highest levels in liver, brain, ovary and testis. Recombinant human DuSP18 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Hood K.L.,et al.Biochem. Biophys. Res. Commun. 298:545-551(2002).
Wu Q.,et al.Biochim. Biophys. Acta 1625:296-304(2003).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 315.00
Cat# PBV11374r
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