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QDPR, human recombinant protein

Quinoid dihydropteridine reductase, DHPR, FLJ42391, PKU2, SDR33C1

     
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Product info
Primary Accession P09417
Concentration 1
Calculated MW 28.2 kDa (267 aa, 1-244 aa + His Tag)
Additional Info
Gene ID 5860
Gene Symbol QDPR
Other Names Quinoid dihydropteridine reductase, DHPR, FLJ42391, PKU2, SDR33C1
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity: > 27 units/ml
Sequence MGSSHHHHHH SSGLVPRGSH MGSMAAAAAA GEARRVLVYG GRGALGSRCV QAFRARNWWV ASVDVVENEE ASASIIVKMT DSFTEQADQV TAEVGKLLGE EKVDAILCVA GGWAGGNAKS KSLFKNCDLM WKQSIWTSTI SSHLATKHLK EGGLLTLAGA KAALDGTPGM IGYGMAKGAV HQLCQSLAGK NSGMPPGAAA IAVLPVTLDT PMNRKSMPEA DFSSWTPLEF LVETFHDWIT GKNRPSSGSL IQVVTTEGRT ELTPAYF
Target/Specificity QDPR
Format Liquid
Storage -20°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol and 2 mM DTT
Citations (0)

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Background

QDPR is a member of the short-chain dehydrogenases/reductase (SDR) family of enzymes. Functioning as a homodimer, QDPR plays an important role in the recycling of tetrahydrobiopterin (BH4), an essential cofactor for the hydroxylation of the aromatic amino acids (tryptophan, tyrosine and phenylalanine). More specifically, QDPR catalyzes the regeneration of BH4 from quinonoid dihydrobiopterin (qBH2), the product generated from the hydroxylation reactions. Mutations in the gene encoding QDPR can lead to phenylketonuria II. Recombinant human QDPR protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

References

Dahl H.-H.M.,et al.Nucleic Acids Res. 15:1921-1932(1987).
Dahl H.-H.M.,et al.Submitted (JUL-1987) to the EMBL/GenBank/DDBJ databases.
Lockyer J.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3329-3333(1987).
Dianzani I.,et al.Hum. Mutat. 12:267-273(1998).
Hsiao K.-J.,et al.Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.

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$ 315.00
Cat# PBV11380r
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