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NME1, human recombinant protein

Non-metastatic cells 1, Nucleoside diphosphate kinase A, NDP kinase A, AWD, GAAD, NB, NBS, NDPK-A, N

     
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Product info
Primary Accession P15531
Concentration 1
Calculated MW 17.1 kDa (152 aa, 1-152 aa)
Additional Info
Gene ID 4830
Gene Symbol NME1
Other Names Non-metastatic cells 1, Nucleoside diphosphate kinase A, NDP kinase A, AWD, GAAD, NB, NBS, NDPK-A, NM23, NM23-H1.
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity is > 180 unit/ml
Sequence MANCERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVGLKF MQASEDLLKE HYVDLKDRPF FAGLVKYMHS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS DSVESAEKEI GLWFHPEELV DYTSCAQNWI YE
Target/Specificity NME1
Format Liquid
Storage -20°C; 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 7.5) containing 10% glycerol and 1 mM DTT
Citations (0)

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Background

Non-metastatic cells 1 (NME1), also known as NM23-H1, originally identified as a candidate metastasis suppressor gene. NME1 is expressed in different tumor types where their levels have been alternatively associated with reduced or increased metastatic potential. Reductions in NME1 expression have been significantly associated with aggressive behavior in melanoma, breast, colon, and gastric carcinomas. On the contrary, high levels of NME1 gene expression are noted in the advanced stage of thyroid carcinomas. Recombinant human NME1 was expressed in E.coli and purified by using conventional chromatography techniques.

References

Rosengard A.M.,et al.Nature 342:177-180(1989).
Gilles A.-M.,et al.J. Biol. Chem. 266:8784-8789(1991).
Wang L.,et al.Cancer Res. 53:717-720(1993).
Dooley S.,et al.Hum. Genet. 93:63-66(1994).
Ni X.,et al.J. Hum. Genet. 48:96-100(2003).

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$ 295.00
Cat# PBV11382r-100
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