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HAGH, human recombinant protein

Hydroxyacylglutathione hydrolase, GLO, GLX2, Glyoxalase II, HAGH1

     
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Product info
Primary Accession Q16775
Concentration 0.5
Calculated MW 31.4 kDa (284 aa, 1-260 aa + His Tag)
Additional Info
Gene ID 3029
Gene Symbol HAGH
Other Names Hydroxyacylglutathione hydrolase, GLO, GLX2, Glyoxalase II, HAGH1
Gene Source Human
Source E.coli
Assay&Purity SDS-PAGE; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Results Specific activity is > 1.8 unit/ml
Sequence MGSSHHHHHH SSGLVPRGSH MGSHMKVEVL PALTDNYMYL VIDDETKEAA IVDPVQPQKV VDAARKHGVK LTTVLTTHHH WDHAGGNEKL VKLESGLKVY GGDDRIGALT HKITHLSTLQ VGSLNVKCLA TPCHTSGHIC YFVSKPGGSE PPAVFTGDTL FVAGCGKFYE GTADEMCKAL LEVLGRLPPD TRVYCGHEYT INNLKFARHV EPGNAAIREK LAWAKEKYSI GEPTVPSTLA EEFTYNPFMR VREKTVQQHA GETDPVTTMR AVRREKDQFK MPRD
Target/Specificity HAGH
Format Liquid
Storage -20°C; 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Citations (0)

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Background

HAGH is a member of the glyoxalase family and a thiolesterase which hydrolyses S-lactoyl-glutathione to reduced glutathione and D-lactate. This protein is a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73 and serves as a pro-survival factor of the p53 family. It exists only as a monomer and binds two zinc ions per subunit. Recombinant human HAGH protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

References

Ota T.,et al.Nat. Genet. 36:40-45(2004).
Daniels R.J.,et al.Hum. Mol. Genet. 10:339-352(2001).
Martin J.,et al.Nature 432:988-994(2004).
Ridderstroem M.,et al.J. Biol. Chem. 271:319-323(1996).
Cordell P.A.,et al.J. Biol. Chem. 279:28653-28661(2004).

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$ 395.00
Cat# PBV11391r
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