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Human CellExpCFD/Adipsin, human recombinant protein

CFD, Adipsin, PFD, DF, Complement factor D

Product info
Primary Accession P00746
Calculated MW This protein rh CFD / Adipsin is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25.2 kDa. The predicted N-terminus is Ile 26. DTT-reduced Protein migrates as 25 kDa in SDS-PAGE.
Additional Info
Gene ID 1675
Gene Symbol CFD
Other Names CFD, Adipsin, PFD, DF, Complement factor D
Gene Source Human
Source HEK 293 cells
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 N/A;
Recombinant Yes
Results The specific activity is >70 pmol/min/ µg.
Target/Specificity CFD/Adipsin
Application Notes Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Format Lyophilized
Storage -20°C; Lyophilized from 0.22 µm filtered solution in 50 mM Tris, 100 mM NaCl, pH 7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Citations (0)

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Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.


Relle M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
White R.T.,et al.J. Biol. Chem. 267:9210-9213(1992).
Niemann M.A.,et al.Biochemistry 23:2482-2486(1984).

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$ 245.00
Cat# PBV11394r
(40 western blots)
Availability: 5-7days
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