Calmodulin, human recombinant protein
CaM, CALM Phosphodiesterase 3':5'-cyclic nucleotide activator, CALM2, PHKD, CAMII, PHKD2, phosphoryl
|Calculated MW||16.8 kDa|
|Other Names||CaM, CALM Phosphodiesterase 3':5'-cyclic nucleotide activator, CALM2, PHKD, CAMII, PHKD2, phosphorylase kinase delta.|
|Application Notes||Reconstitute in water or an appropriate buffer (TBS, PBS, etc)|
|Storage||-20°C; Lyophilized from a salt free solution.|
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Provided below are standard protocols that you may find useful for product applications.
Calmodulin (CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions. CaM mediates processes such as inflammation, metabolism, apoptosis, muscle contraction, intracellular movement, short-term and long-term memory, nerve growth and the immune response. Calmodulin is expressed in many cell types and can have different subcellular locations, including the cytoplasm, within organelles, or associated with the plasma or organelle membranes. Many of the proteins that CaM binds are unable to bind calcium themselves, and as such use CaM as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in the endoplasmic reticulum, and the sarcoplasmic reticulum. CaM undergoes a conformational change upon binding to calcium, which enables it to bind to specific proteins for a specific response. CaM can bind up to four calcium ions, and can undergo post-translational modifications, such as phosphorylation, acetylation, methylation and proteolytic cleavage, each of which can potentially modulate its actions.
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