|Calculated MW||43.6 kDa (20-401 aa + N-terminal polyhistidine tag)|
|Other Names||CTSE, Cathepsin E, Procathepsin E|
|Application Notes||Reconstitute with water to 0.5-1 mg/ml. Aliquot and store at –20°C. Avoid repeated freezing and thawing cycles.|
|Storage||-20°C; Lyophilized from 5 mg/ml solution in a proprietary buffer|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Cathepsin E (EC: 126.96.36.199) (CTSE) is an intracellular gastric aspartyl protease. It was originally identified as a cathepsin D-like acid protease. It is active in acidic conditions in a pH range from 2.5 to 5.5. In vitro experiments have identified several CTSE substrates including insulin beta chain, neurokinin, and FGF. Although the function of CTSE is not completely understood, it has been implicated in several physiological and pathological processes. CTSE is required for antigen presentation on class II MHC molecules. CTSE-deficient macrophages show abnormalities such as autophagy. Like many other cathepsins, CTSE has emerged as a therapy target for cancers, such as pancreatic ductal adenocarcinoma (PDAC). In addition to PDAC, CTSE is also overexpressed in gastric carcinomas and cervical and lung adenocarcinomas. The possible involvement of CTSE in neurodegeneration has also been reported. This protease has a specificity similar to that of pepsin A and cathepsin D. It is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is found in more than half of gastric cancers.
Azuma T.,et al.J. Biol. Chem. 264:16748-16753(1989).
Azuma T.,et al.J. Biol. Chem. 267:1609-1614(1992).
Finley E.M.,et al.J. Biol. Chem. 269:31259-31266(1994).
Tatnell P.J.,et al.Biochim. Biophys. Acta 1625:203-206(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.