Active SIRT7, human recombinant protein
NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7
|Calculated MW||50.1 kDa (2-400 aa + N-terminal polyhistidine tag).|
|Other Names||NAD-dependent deacetylase 7; SIR2-like protein 7; Sirtuin 7; SIR2L7; Silent Information Regulator 7|
|Storage||-80°C; 2 mg/ml in 50 mM Tris, pH 8.0, 100 mM NaCl, containing 5 mM DTT and 20% glycerol.|
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Provided below are standard protocols that you may find useful for product applications.
The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group. There are seven human sirtuins, which have been designated SIRT1-SIRT7. Recently, SIRT7 has been shown to activate transcription by RNA polymerase I and deacetylate p53. SIRT7 prevents progressive functional deterioration of the heart, and is suggested to play an important role in regulation of stress responses and cell death in the heart.
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de Nigris F.,et al.Br. J. Cancer 86:917-923(2002).
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