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Irisin, Active, human recombinant protein

Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-conta

Product info
Primary Accession Q8NAU1
Calculated MW ~13.00 kDa
Additional Info
Gene ID 252995
Gene Symbol FNDC5
Other Names Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE ; ≥95%
Assay2&Purity2 N/A;
Recombinant Yes
Sequence Full-length untagged Irisin (112 amino acids)
Target/Specificity Irisin
Application Notes Reconstitute to 0.1 mg/ml with sterile water
Format Lyophilized powder
Storage -20°C; Lyophilized from PBS.
Citations (0)

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Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.


Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bostrom P.,et al.Nature 481:463-468(2012).

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$ 295.00
$ 945.00
Cat# PBV11409r-10
Availability: 5-7days
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