Irisin, Active, human recombinant protein
Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-conta
|Calculated MW||~13.00 kDa|
|Other Names||Fibronectin Type III Domain-containing Protein 5, FNDC5 (cleaved); Fibronectin Type III Repeat-containing Protein 2, FRCP2 (cleaved).|
|Assay&Purity||SDS-PAGE ; ≥95%|
|Sequence||Full-length untagged Irisin (112 amino acids)|
|Application Notes||Reconstitute to 0.1 mg/ml with sterile water|
|Storage||-20°C; Lyophilized from PBS.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Irisin is a recently discovered exercise-induced myokine, which is secreted by skeletal muscles and produced by cleavage of the FNDC5. Studies show that Irisin stimulates mitochondria uncoupling protein-1 (UCP-1; a regulator of thermogenic capability of brown fat) expression, so Irisin can upregulate white to brown fat conversion and improve systemic metabolism by increasing energy expenditure. Hence, Irisin is a potential new drug target in the study of metabolic disorders, such as obesity and type 2 diabetes mellitus (T2DM). Moreover, FNDC5-like receptors are conserved in vertebrates and critical for neuronal development.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Bostrom P.,et al.Nature 481:463-468(2012).
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.